You can access the preliminary program in the following link:
Click on the workshop title to see detailed information.
Organized by Carlos Salomon & Larry Chamley.
Summary: The past decade has observed an extraordinary explosion of research in the field of extracellular vesicles (EVs). There are different population of EVs including nanovesicles (some of which are exosomes) microvesicles and in the specific case of the human placenta, macrovesicles. As this very rapidly expanding field grows we are learning that within the different sized vesicle populations there are additional specialized subsets of EVsthat may have specific functions. . For example, exosomes may be sub-classified as exomeres, exo-S and exo-L (accordantly to their size) Regardless of the type, all EVs carry complex cargos including various nucleic acids, proteins and lipids all of which may be biologically active. Placental EVs are targeted to specific maternal organs and have the potential to regulate maternal cellular and organ function during pregnancy. Thus, placental EVs may be major players in feto-maternal communication. Since placental EVs are present in the maternal blood they are also potentially readily accessible biomarkers of fetal well-being.
Anne Cathrine Staff, MD, PhD. Professor, University of Oslo, Norway .Head of Research, Consultant, Division of Obstetrics and Gynacology, Oslo University Hospital, Norway.
Mariana Farina. Head of Laboratory of Physiopathology of Placenta, CEFYBO-UBA-CONICET, Bs As, Argentina.
Summary: This workshop is dedicated to discuss similarities and differences between the two common and lifethreatening placental syndromes preeclampsia and fetal growth restriction (FGR). The topics will include pathophysiology, placental morphology and function, biomarkers and relation to future maternal and offspring health. Dysfunctional placental function is common for both preeclampsia and FGR. Abnormal placentation and abnormal trophoblast invasion and function is common both for early-onset preeclampsia and FGR. New-onset hypertension after gestational week 20 and FGR is today one of the clinical criteria to define preeclampsia in many revised definitions, in the absence of new-onset proteinuria. In this workshop, we will discuss the similarities and differences between these placental syndromes and discuss whether they represent separate or partly overlapping etiologies and pathophysiologies.
- Chris Redman, University of Oxford, United Kingdom
- Alicia Damiano, University of Buenos Aires, Argentina
- Tu'uhevaha Kaitu'u-Lino
- Juan Arroyo
- Stefan Hansson, University of Lund, Sweden
Ulrike Kemmerling, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Chile
Summary: Infections during pregnancy lead directly and indirectly to a spectrum of adverse maternal and fetal/placental effects. Congenital transmission of pathogens is the consequence of complex interactions among the pathogen, maternal and fetal/newborn immune responses, and placental factors. Here we will discuss different topics about infection with different pathogens during pregnancy including the Shiga toxin producing Echerichia coli, Trypanosoma cruzi the protozoan parasite that causes Chagas disease and Zika virus. Intrinsic factors of the different pathogens, placental factors as well as the inflammatory/immune response triggered by those pathogens will be discussed.
- Dr. Huishu Liu, Guangzhou Women and Children’s Medical Center, China.
- Dr. Alejandro Schijman, INGEBI, Argentina
- Dr. Claudia Duarte dos Santos, Instituto Carlos Chagas, Fiocruz, Río de Janeiro, Brasil
- Dr. Flavia Sacerdoti, Universidad de Buenos Aires, Argentina
- Dr. Indira U Mysorekar, Centre for Reproductive Health Sciences, Washington University School of Medicine, USA
- Dr. Ulrike Kemmerling, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Chile
Christiane Pfarrer. University of Veterinary Medicine Hannover (Hannover, Germany)
Derek E. Wildman. University of South Florida (Tampa, USA)
Summary: The placenta is one of the most variable features of mammalian anatomy and physiology. Because no other species has a placenta that is identical to the human it has been challenging to find appropriate animal models for comparative experimental studies. Each animal model species has advantages and disadvantages. In this workshop we will work to develop a workflow for deciding which species is appropriate for specific research questions. Some species may share anatomical or physiological features with human placentas while lacking good genomic resources while other species may have strong genomic and transgenic resources but have placental anatomy that diverges greatly from that seen in humans. We will also consider the placenta from the broad definition given by H.W. Mossman, any apposition of fetal and maternal tissue. With this broad definition in mind it is possible to consider placentation in non-mammalian species such as reptiles and invertebrate onychophoran velvet worms.
- Priyadarshini Pantham, University of California San Diego, USA
- Hanna Allerkamp, University of Auckland, NZ
- Anthony Carter, U Odense, Denmark
- Claudio Barbeito, National Scientific and Technical Research Council, Argentina
- Julienne Ruthorford, University of Illinois, USA
- Julie Baker, Stanford, USA
- Christiane Pfarrer, University of Veterinary Medicine Hannover, Germany
- Derek Wildman, University of South Florida, USA
Marijke Faas, Department of Pathology and Medical Biology, University Medical Center Groningen, the Netherlands
Rosanna Ramhorst, Immunopharmacology Laboratory. School of Sciences, IQUIBICEN-CONICET and University of Buenos Aires, Argentina.
Summary: Immune responses during pregnancy change, in order to tolerate the fetal semiallograft. The importance of the adaptations to pregnancy are obvious from the fact that many pregnancy complications are associated with aberrant immunological adaptations. During this symposium immunological adaptations in the mother during healthy pregnancy are presented both peripheral immune changes as well as changes in the placental bed. Actors that may interfere with these immune responses will be discussed as well as aberrant immune responses in some pregnancy complications will be discussed. Finally, developing fetal immune responses will be discussed and how these could be influenced by various maternal factors. During the symposium there will be plenty of time for questions and discussions.
- Ana Zenclussen: Experimental Obstetrics and Gynecology, Medical Faculty, Otto-von-Guericke University, Magdeburg, Germany
- Silvia Daher: Laboratory of Obstetrics Investigation, Department of Obstetrics Universidade Federal de São Paulo, Brazil
- Claudia Perez Leiros: Immunopharmacology Laboratory. School of Sciences, IQUIBICEN-CONICET and University of Buenos Aires, Argentina.
- Gendie Lash: Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
- Marijke Faas, Department of Pathology and Medical Biology, University Medical Center Groningen, the Netherlands.
Dr. Padma Murthi, Monash University, Melbourne, Australia.
Dr. Lynda Harris, University of Manchester, UK
Summary: The placenta plays many crucial roles for the maintenance of pregnancy. It is the chief regulator of fetal development by facilitation of transfer of nutrients, gases and waste products between the mother and fetus; synthesising hormones to support feto-placental growth; remodel the uterine spiral arterioles to establish an optimum vascular environment; and prevent and protect not only from immune-mediated rejection of the fetus but also from infectious agents and environmental insults. As such adequate placental function is instrumental for a successful pregnancy outcome and abnormalities of placental development and function contribute to major pathologies of pregnancy including spontaneous preterm birth, fetal growth restriction, and preeclampsia. Assessment of placental function across gestation is challenging due to the risks for the mother and the developing fetus. Thus far, reports on human placental development and function comes from studying placentas from pathological and uncomplicated pregnancies collected at third trimester or term deliveries. However, molecular changes in the placenta may initiate processes that lead to placental pathologies, well before clinical signs of pregnancy complications are detected. In this workshop we will discuss on novel technologies used in placental research in defining the structure and function of the human placenta, their use in clinical settings and also the model systems that have been developed to better understand abnormal development leading to pregnancy pathologies.
Theresa Powell, PhD. University of Colorado, Aurora, Colorado, USA.
Andrea Leiva, PhD, Pontifical Catholic University of Chile, Santiago, Chile.
Summary: The human placenta is critical for pregnancy success through its roles as an endocrine organ, establishing the relationship between maternal and fetal blood supplies and in nutrient delivery and gas exchange to ensure adequate growth. Multiple cellular signaling pathways are responsible of the regulation of these critical functions. This workshop is aimed to review some of the placental cellular signaling critical for placental development and highlight the cellular signaling events that modulate placental function, pregnancy outcome and life long health.
- Amanda Sferruzzi-Perri, PhD, University of Cambridge, UK
- Cathy Vaillancourt, PhD, Institut national de la recherche scientifique (INRS), Montreal, Canada
- Martin Post, PhD, Hospital for Sick Children, Toronto, Canada
- Theresa Powell, PhD, University of Colorado, USA
- Elena Silva, PhD, University of Colorado, USA
- Andrea Leiva, Pontifical Catholic University of Chile, Santiago, Chile
Organized by Carolyn Salafia & Lopa Leach
More details coming soon.
Wendy Robinson. Department of Medical Genetics, University of British Columbia BC Children’s Hospital Research Institute (BCCHR), Vancouver, Canada.
Paola Casanello. Departments of Obstetrics & Neonatology, School of Medicine Pontificia Universidad Católica de Chile, Santiago, Chile.
Summary: The placenta field has been strongly molded in recent years by the concept of epigenetic determinants of health. From less than 5 papers published in this field in 2005 to more than 80 in 2018, we are gaining a glimpse of how DNA methylation and chromatin remodeling are associated with the way maternal conditions and exposures during pregnancy are sensed by the placenta and compromise fetal and postnatal physiological responses. Epigenetic marks have often been interrogated independently of genetic variation. However, there is strong evidence showing the interaction between genetics and environment in mediating epigenetic variation. In this workshop we will offer talks with different looks from senior and young researchers in the field, with the objective of setting a fructiferous discussion on the current challenges that genetic and epigenetic studies in the placenta confront today.
- Dr Wendy Robinson, Department of Medical Genetics, University of British Columbia BC Children’s Hospital Research Institute (BCCHR), Vancouver, Canada
- Dr. Richard Saffery, Cancer & Disease Epigenetics (CDE) laboratory at Murdoch Childrens University of Melbourne. Melbourne, Australia
- Dr. Saumen Paul, The University of Kansas Medical Center. Kansas City, Kansas, USA
- Dr. Paola Casanello, Departments of Obstetrics & Neonatology, School of Medicine Pontificia Universidad Católica de Chile, Santiago, Chile
Ana Franchi, PhD. Laboratory of Physiopathology of Pregnancy and Labor, CEFYBO (CONICET-UBA).
Federico Jensen, PhD. Laboratory for Immunology of Pregnancy, Center for Pharmacological and Botanical Studies, Medical Faculty, Buenos Aires University, Buenos Aires, Argentina.
Summary: Preterm birth, defined as birth occurring before 37 weeks of gestation, is a leading cause of neonatal mortality and morbidity as well as the second cause of dead in children under 5 years. 15 million babies are born prematurely every year, representing 5 to 18% of pregnancies worldwide. In addition, due to immaturity of multiple organ systems, neonates born preterm are more susceptible to develop short-term complications as well as neurodevelopmental disorders, such as cerebral palsy, intellectual disabilities, and vision and hearing impairments during post-natal life. Thus, despite extensive efforts, preterm birth has remained an intractable medical and public health challenge. Although it is considered a syndrome attributable to multiple pathogenic processes, intrauterine and systemic infection and/or inflammation are causally linked to preterm birth. In this workshop we will discuss the latest advances in the understanding of preterm birth pathophysiology.
- Dr. Nardhy Gomez-Lopez, Associate Professor, Perinatal Research Initiative, Wayne State University School of Medicine. Section Head of the Perinatal Immunobiology Unit, Perinatology Research Branch NIH/NICHD,C.S. Mott Center for Human Growth and Development
- Dr. Kang Chen. Wayne State University and Mucosal Immunology Studies Tram, National Institute of Allergy and Infectious Diseases, National Institutes of Health, USA.
- Dr Felipe Vadillo-Ortega. Universidad Nacional Autónoma de México. UNAM, School of Medicine, México.
- Dr Gang Sun. Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
Dr. Carlos Escudero. Red Iberoamericana de Alteraciones Vasculares Asociadas a Trastornos del Embarazo (RIVA-TREM). Universidad del Bio Bio
Dr. James M. Roberts. Global Pregnancy Collaboration and Magee-Womens Research Institute, Department of Obstetrics and Gynecology Epidemiology and Clinical and Translational Research University of Pittsburgh.
Summary: Women with adverse pregnancy outcomes, including preeclampsia, gestational diabetes, preterm delivery, have excess risk of later life cardiovascular disease (CVD). Mechanisms of these disorders could be associated with an underlying high-risk vascular phenotype, that may have been programed during intrauterine life. Since the placenta is a highly vascularized tissue, it may constitute a unique source of information of what and how vascular structure/function is affected in women with adverse pregnancy outcomes. Even more, placental evidence of impaired vascular function may serve as “a fingerprint” that may alert us to what would be the vascular response of women and their offspring in future life. In this symposium we aim to analyze evidence of impaired placental vascular structure/function and its relevance to future cardiovascular risk. This may suggest potential underling mechanisms and pharmacological targets. The relationship of placental structure/function to later maternal disease could provide unique insights in the field and help us to move forward in both the understanding of cardiovascular disease in women and to alert health care systems about future cardiovascular risk.
- Dr. Janet Catov. Department of Obstetrics, Gynecology and Reproductive Sciences, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA; Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, PA, USA; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
- Dr. William Parks. Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada.
- Dr. Marta Viana. Department of Chemistry and Biochemistry, Facultad de Farmacia, CEU San Pablo University – CEU Universities, Madrid. Spain. Red Iberoamericana de Alteraciones Vasculares Asociadas a Trastornos del EMbarazo (RIVA-TREM), Chillán, Chile.
- Dr. Natalie Hannan. Mercy Perinatal, Mercy Hospital for Women, Melbourne, Australia. Translational Obstetrics Group, Department of Obstetrics and Gynaecology. University of Melbourne, Heidelberg, Australia
Christian Wadsack, Assoc. Prof., PhD. Vice-dean of Doctoral Studies. Medical University of Graz, Department of Obstetrics and Gynecology.
Verónica White, Assoc. Inv. Faculty of Medicine, University of Buenos Aires, CEFYBO CONICET. Laboratory of Reproduction and Metabolism.
Summary: Maternal metabolic derangements in pregnancy are a worldwide growing problem and can induce placental and fetal anomalies. Notably, as a result of the disturbed intrauterine environment offspring´s metabolism might be compromised and may lead to long-lasting alterations as well. Affected newborns are at increased risk of developing related diseases like obesity, type-2 diabetes or cardiovascular disorders during life. The research in the field has explored and identified that excess of nutrients, a disturbed lipid profile, an altered hormonal milieu together with an imbalance of antioxidant/pro-inflammatory substances are the main stressors and causes of the anomalies observed in placentas, fetuses and offspring. This workshop focusses on the underlying mechanisms of these alterations on the feto-placental axis and offspring. A holistic view of this specific topical problem will be achieved through presentation of different experimental models and including the spatial-temporal axis of pregnancy.
- Dr. Pascale Chavatte Palmer, DVM, PhD, HDR, French National Institute for Agricultural Research | INRA • Biologie du Développement et Reproduction (BDR) DVM, PhD, HDR, Paris, France
- Dr. Christianne Albrecht, PhD, Institute of Biochemistry and Molecular Medicine. Universität Bern | UniBe, Bern, Switzerland.
- Veronique Ferchaud-Roucher, University of Colorado, OB/Gyn Department, Denver, USA
- Ilaria Del Gaudio, PhD, Department of Obstetrics and Gynecology, Medical University of Graz, Graz, Austria.
- Dolores Busso, PhD, Departament of Nutrition, Diabetes and Metabolism, Pontifical Catholic University of Chile, Santiago de Chile, Chile.
Lopa Leach. School of Life Sciences, Faculty of Medicine, University of Nottingham, Nottingham, United Kingdom.
Summary: This workshop will ask 3 experts to each speak to their specialization- cutting edge evidence as to why they think that the mother, the fetus or the placenta dictates the size of the newborn. The audience will quiz them and we will reach a conclusion as to whether there is synthesis of physiology, maternal/fetal genes, parental imprinting in this era of epigenetics. We expect the experts to each present key findings in 15 min, followed by 15 min Q and A.
Workshop confirmed speakers:
- Carlos Salomon, University of Queensland, Austria.
- Gernot Desoye, University of Graz, Austria.
- Wrap up: Lopa Leach & Carolyn Salafia.
Early and Mid Career Researchers Activities:
- ECR activity: “Meet the Expert”: Organized by Maria Laura Ribeiro, Jimena Beltrame, Daiana Vota, Marisol Castillo Catrejon, Lawrence Hsu Lin and Micaela Sordelli.
- Do and doesn’t in oral and poster presentations
- How to make a successful presentation, worthy of a travel award
- What to get international research funding
- How to have a great collaboration and how to make it successful
- Criteria to order authors in a manuscript
- Translational medicine: the best experimental model for a clinical question
- Big data analysis
- How to choose the best journal to publish your data
- Challenges and opportunities for researchers from developing countries
- Finding academic mentors
- Gender discrepancies in science
- “Mid Career Session”: This activity consists of eight short presentations from Mid Career Investigators, selected by abstract ranking.
Yoel Sadovsky, Executive Director, Magee Womens Research Institute, Elsie H Hillman Chair of Women´sHealth Research, Distinguished Professor of OBGYN, Microbiology and Molecular Genetics, Associate Dean, Women’s Health Research and Reproductive Sciences.
Martin Knöfler is Associate Professor at the Medical University of Vienna and the current European Editor of Placenta. 2001. His main research interests include molecular mechanisms and signalling pathways regulating human placental development, trophoblast differentiation, decidualization as well as the trophoblast-decidual cross-talk.
Professor Tony Perkins is a biochemist with particular interests in anti-oxidant enzymes systems in the human placenta. His research is focused on mitochondrial dysfunction and how oxidative stress influences placental cell turnover in complications of pregnancy such as preterm birth, fetal growth restriction and preeclampsia. Academic for the Health Group (2012-2018). He is currently on research sabbatical.
In this educational session, the Editors of Placenta will discuss diverse aspects related to composing, assembling, writing, revising and publishing a scientific paper. In detail, Y. Sadovsky will summarize the structure of manuscript, explain the content of its different sections, and emphasize how previous published work is appropriately cited. A. Perkins will discuss the importance of choosing the right journal plus measures of publication quality such as the impact factors and citation rates. He will also elaborate on the peer-review process and the response to reviewers’ critiques. Finally, M. Knöfler will report on the requirements for authorship, language and style of a paper, and discuss ethics and plagiarism in science. Attendees at the session will become familiar with the considerations, effort, activities, and processes required to successfully publish a paper. There will be time for questions and answers, and a lively discussion.
Dr. Zamudio was trained in Evolutionary Biology/Anthropology at the University of California, Los Angeles, and the University of Colorado in Boulder. Much of her work has focused on placental hypoxia (high altitude) and applied ulrasonography for quantification of blood flows, oxygen and nutrient delivery and uptake in mother and fetus. As Director of Research in the Department of Obstetrics and Gynecology and the Center for Abnormal Placentation at Hackensack University Medical Center, she has been engaged in studies of Abnormally Invasive Placenta (AIP, aka Placenta Accreta Spectrum-PAS). Clinical-translational work, funded by the NIH Human Placenta Project, has focused on ultrasound-based quantitative diagnosis of AIP, clinical outcomes in mother and neonate, and the pathophysiology of AIP at the molecular level.
Dr. Lauren Aleksunes is Professor in the Ernest Mario School of Pharmacy and the Environmental and Occupational Health Sciences Institute at Rutgers University. Director of the Rutgers Toxicology Graduate Program. In 2019, Lauren received the Outstanding Young Investigator Award from the Women in Toxicology.
More information coming soon.
Brian Cox is an associate professor in the Dept. of Physiology at the University of Toronto and an expert in computational analysis of biological data sets with an emphasis on placental and trophoblast biology and pathology. He is an advisor to the NIH initiatives Placenta Atlas Tool and the Human Placenta Project.
In this interactive tutorial you will log on to the Placenta Atlas Tool (PAT) and run example case study investigations. You will learn the layout of the tool, available system resources and creation of a workspace to save your analysis results. Interested attendees should create an account at https://pat.nichd.nih.gov. The account is free. Tutorial will explore using PAT for investigating placental pathology and biology using key word libraries, images and gene expression analysis.
María Victoria Eusevi, Biologist (University of Buenos Aires, Argentina), Certificate of Proficiency in English (University of Cambridge) Editor of scientific papers.
Papers have a great importance in the life of any researcher, as their daily work involves not only reading but also writing papers. Spanish-speaking researchers have the additional difficulty that English is not their language and thus need to find the best way to express their ideas and thoughts clearly. Thus, this short talk has been designed to provide Spanish-speaking researchers with simple tips and tools to write their manuscripts with a correct, direct, and simple English language.
Premeeting Clinical Symposium
The Premeeting Symposium "Scientific Advances of Clinical Impact" is a unique opportunity to listen to seven worldwide recognized experts in the areas of Reproductive Medicine, Reproductive Immunology, Gestational Metabolic Diseases, Fetal Programming and Obstetrics Disorders like preeclampsia and postpartum hemorrhage, as well as taking insights in the new technology that allows the identification of placental function disorders.
Range of Topics
- Cell Signaling in the Placenta
- Cellularity in the Placenta
- Comparative Placentation
- Decidua-Trophoblast Interaction
- Early Pregnancy
- Embryo Development
- Extracellular Vesicles and MicroRNAs
- Fetal Membranes
- Feto-Placental Growth
- Gestational Diseases
- Immunology of Pregnancy
- Infections in Pregnancy
- Intrauterine Programming
- Metabolic Diseases in Pregnancy
- Micro and Macro Nutrients in Development
- Mother to Fetus Communication
- Novel Technology for Studying the Placenta
- Periconceptional Health
- Placental Cell Culture/Cell lines
- Placental Disorders
- Placental Hormones
- Placental Transport
- Postpartum hemorrhage/invasive placenta
- Pregnancy Complications
- Procesess of Apoptosis and Autophagy in Develpment
- Process of Angiogenesis in the Placenta
- Processes of Trophoblast Invasion and Differentiation
- Stem Cells
- Transcriptional Regulation in the Placenta
- Trophoblast Biology